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What is Zestril?
Zestril is a long-acting ACE inhibitor that is primarily used to control blood pressure, treat heart attacks and congestive heart failure. It contains Lisinopril as active ingredient, which works by blocking certain enzyme in the body that causes blood vessels to constrict. By producing vasodilative effect, the drug potently lowers blood pressure. It differs from other ACE inhibitors by having long half-life and tissue penetration. The drug is supplied in tablets for oral administration with various strengths of the active ingredient.
When is Zestril indicated?
Zestril indications are similar to those for all other ACE inhibitors, and namely: controlling blood pressure, treating congestive heart failure and acute myocardial infarction. It is also used to prevent renal and retinal complications of diabetes, that is diabetic nephropathy. When indicated for improving survival after a heart attack, patients should concomitantly receive standard treatments as thrombolytics, beta-blockers and aspirin. The drug is also approved for hypertension treatment in children over 6 years of age.
How to take Zestril?
Zestril initial dose for hypertension treatment in adults is 10 mg once daily. The dosage is then adjusted according to individual response and usually ranges from 20 to 40 mg per day given in a single daily dose. The starting dose for hypertension in children is 0.07mg/kg (up to 5mg) once daily, which can be later up-titrated to 0.61mg/kg once daily (up to 40 mg). For heart failure treatment the drug is administered in a dose of 5 mg together with diuretics. To improve survival following heart attack the drug is administered in a dose of 5 mg within first 24 hours, which is followed by another 5 mg after 24 hours and then 10 mg after 48 hours followed by 10 mg once daily for 6 weeks. Patients with poor kidney function require individual dose adjustment.
What are Zestril side effects?
Zestril may cause headache, dizziness, tiredness and lightheadedness as the body adjusts to the drug. Other side effects may be cough, irregular heartbeats, chills, sore throat, abdominal pain, joint pain, change in urine output, wheezing, difficulty breathing, allergic reactions. Report to your healthcare provider about any side effects you experience while receiving the drug.
When is Zestril contraindicated?
Zestril is contraindicated at individual intolerance to ACE inhibitors, to patients with idiopathic or hereditary angioedema, as well as to pregnant and breastfeeding women. It shouldn’t be coadministered with aliskiren in diabetics.