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Methotrexate is a drug belonging to the class of preparations known as immunosuppressants and antimetabolites. It works by inhibiting the reproduction of certain cells in the body and reducing the immune system activity. This drug is used for the treatment of severe forms of psoriasis, severe psoriatic arthritis and active rheumatoid arthritis. Methotrexate is usually used when other treatments are ineffective.

Methotrexate 2.5 mg

Q-ty Price per unit Bonus pills    
30 pills $50.40 $ 1.68 ADD TO CART
60 pills $77.40 $ 1.29 ADD TO CART
90 pills $104.40 $ 1.16 + 8 Bonus pills ADD TO CART
What is Methotrexate?
Methotrexate is a very strong antimetabolite drug. It is used for the treatment of a variety of serious conditions:
  • certain types of cancer (trophoblastic tumors, acute leukemias, non-Hodgkin lymphomas, sarcoma, breast, head, skin, neck, lung cancer and some others);
  • mycosis fungoides;
  • severe forms of psoriasis;
  • psoriatic and rheumatoid arthritis;
  • lupus;
  • ankylosing spondylitis, etc.
How does it work?
Methotrexate has an immunosuppressive effect. It also works by suppressing DNA synthesis and repair and slowing down the division of cells. Fast-growing tissues like cells of the embryo, malignant tumors, bone marrow, epithelium of the intestine, bladder and mouth are particularly sensitive to Methotrexate.

How to take Methotrexate?
The dosage and duration of the treatment with Methotrexate should be individually tailored and depends on the indications, treatment plan, chemotherapy regimen and how well the patient tolerates and responds to this medication. The doses are calculated basing on the patient’s total body area and weight. These pills should be taken before a meal, one dose each week (NOT every day).

When is Methotrexate contraindicated?
This drug should not be used in patients hypersensitive to any of its components. Methotrexate is likely to harm a fetus, so females must not use it during pregnancy; moreover, all women and men on a high-dose treatment plan should take contraceptive precautions while on Methotrexate and for 3 months after discontinuation of the drug. It should not be taken by breastfeeding women as well.
Methotrexate is also contraindicated patients suffering from hematologic disorders (bone marrow hypoplasia, decrease in the number of red blood cells, white blood cells or platelets), acute infections, immunodeficiency and abnormal liver or kidney function. Alcohol can considerably increase the risk for liver damage while using Methotrexate, so it should be avoided.

What are the side effects of Methotrexate?
This drug can cause a decrease in the number of white blood cells making it easier for the patient to get an infection. Therefore, certain precautions should be taken to reduce the risk of possible infections. The most common adverse reactions of Methotrexate include loss of appetite, nausea, diarrhea, abdominal discomfort, mouth ulcers and sore mouth, sore throat, skin rash and some others.