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Lisinopril is an ACE inhibitor with prolonged action indicated for the therapy of hypertension as well as for the prevention of its complications. This drug is a vasodilator, it widens the blood vessels and thus helps the heart pump blood and facilitates the delivery of blood to all body organs and systems. It can also be used for the therapy of heart failure. Lisinopril is contraindicated in pregnant women and in those hypersensitive to it or to other inhibitors of ACE.
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What is Lisinopril?
Lisinopril is an inhibitor of the angiotensin converting enzyme. It is usually supplied in tablets used for oral administration. Lisinopril is used as a treatment for congestive heart failure and high blood pressure. Lisinopril is also used to improve the survival rate of patients who suffered from a heart attack.

What are the indications for using Lisinopril?
Lisinopril in indicated for people with the following conditions:

  • Hypertension – a condition during which the blood pressure repeatedly exceeds 140 over 90 mmHg. In order to treat hypertension, Lisinopril can either be used alone or concomitantly with other antihypertensive agents.
  • Heart failure – inability of the heart to properly pump the blood throughout the body. During this condition Lisinopril is usually used as an adjunctive therapy for patients who do not respond well to digitalis and diuretics.
  • Acute myocardial infarction – changes that occur in the heart muscle due to sudden deprivation of circulating blood. Lisinopril can be used within 24 hour of myocardial infarction to increase the survival rate. Aside from this medicine the patients should also receive standard recommended treatment, which includes beta-blockers, aspirin, and thrombolytics.

What is the dosage of Lisinopril?
The recommended dosage for patients with essential hypertension who are not receiving diuretic therapy, the initial dosage is 10 mg once per day. Dosage is then adjusted if the blood pressure remains high. The usual dosage is around 20 to 40 mg per day taken once per day. This dosage can be increased; however, greater doses of 80 mg and up do not yield greater effect. Therefore, if blood pressure cannot be controlled using Lisinopril alone, a small dose of diuretics should be added (12.5 mg of Hydrochlorothiazide is usually very effective).

What are the contraindications for using Lisinopril?
Lisinopril is contraindicated in people who are hypersensitive to the components of this product. Also, people with angioedema (a condition similar to hives, which affects deep layers of the skin), which occurred as a result of previous treatment using inhibitors of angiotensin converting enzyme should not use this medicine.

What are the adverse effects of Lisinopril?
Lisinopril is usually very well tolerated. Most of the side effects are usually mild and transient. The most common side effects include asthenia, fatigues, hypotension, diarrhea, nausea, vomiting, headache, paresthesia, dizziness, decreased libido, vertigo, cough, rash, and in rare cases improtence.